Typically that depends upon YOUR FOOT. Anytime that the engine is in load, and it is tuned rather on the "rich" side, then yes, fuel economy will suffer. But if you "cruise" the highway, without going into positive pressure as much (that's based upon your driving habits) then no, you can have pretty good fuel economy. No way to know this until you've completed the setup.
And remember, T3/T4 hybrids come in MANY sizes, flavors and colors.. The number T3 and T4 determine general size for cartridge and turbine housings.