Where I'm legit lanky as fuck and my forearms are longer than most peoples I find the standard hunched over position more comfortable, and I like having the ability to get around quickly if the need arises.
To me making an R1 practical would be simple. Lower pegs, softer/thicker seat like you said, heated grips/gloves for cold weather, michelin pilot road 3's for less than desirable weather, perhaps a little bit softer suspension, change the clip ons and get some thicker grips with shorty levers for the two finger action.
Just a bunch of little stuff like that and to me that would be better than a harley or any other bike bought for "practicality"
Oh and a sport touring screen to get the wind off your face when you're sitting more upright.
Not to mention the smoothness of an inline 4 is very pleasant at lower speeds, vs that rough, vibrating bullshit of a v twin :rolf: